Open AccessMesenchymal Stem Cells and Cardiomyocytes Interplay to Prevent Myocardial Hypertrophy
Author(s) -
Cai Benzhi,
Tan Xueying,
Zhang Yong,
Li Xingda,
Wang Xinyue,
Zhu Jiuxin,
Wang Yang,
Yang Fan,
Wang Baoqiu,
Liu Yanju,
Xu Chaoqian,
Pan Zhenwei,
Wang Ning,
Yang Baofeng,
Lu Yanjie
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0032
Subject(s) - mesenchymal stem cell , calcineurin , microbiology and biotechnology , stem cell , vascular endothelial growth factor , transplantation , nfat , cancer research , biology , endocrinology , medicine , chemistry , vegf receptors
In this study, bone marrow‐derived mesenchymal stem cells (BMSCs) were indirectly cocultured with neonatal rat ventricular cardiomyocytes in vitro or intramyocardially transplanted into hypertrophic hearts in vivo. The results showed that isoproterenol‐induced typical hypertrophic characteristics of cardiomyocytes were prevented by BMSCs in the coculture model in vitro and after BMSC transplantation in vivo, providing the first evidence for the treatment of myocardial hypertrophy using BMSCs.