Open AccessIntracarotid Infusion of Mesenchymal Stem Cells in an Animal Model of Parkinson's Disease, Focusing on Cell Distribution and Neuroprotective and Behavioral Effects
Author(s) -
Cerri Silvia,
Greco Rosaria,
Levandis Giovanna,
Ghezzi Cristina,
Mangione Antonina Stefania,
Fuzzati-Armentero Marie-Therese,
Bonizzi Arianna,
Avanzini Maria Antonietta,
Maccario Rita,
Blandini Fabio
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0023
Subject(s) - mesenchymal stem cell , medicine , neuroprotection , parkinson's disease , apomorphine , pharmacology , mptp , systemic administration , stem cell , neuroscience , pathology , in vivo , dopamine , disease , biology , dopaminergic , microbiology and biotechnology , genetics
Homing of intraarterially infused rat mesenchymal stem cells (rMSCs) in the brain of rats bearing a 6‐hydroxydopamine (6‐OHDA)‐induced lesion of the nigrostriatal tract was evaluated to establish whether the toxin‐induced damage enables MSC passage across the blood‐brain barrier (BBB) or if transient BBB disruption is necessary. Appreciable delivery of rMSCs to the brain of lesioned animals occurred only after mannitol pretreatment. rMSC infusion induced progressive normalization of the pathological response to apomorphine administration.