Open AccessEffect of TGF‐β1 Stimulation on the Secretome of Human Adipose‐Derived Mesenchymal Stromal Cells
Author(s) -
Rodríguez Tania M.,
Saldías Alejandro,
Irigo Marcelo,
Zamora Jorge Velasco,
Perone Marcelo J.,
Dewey Ricardo A.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0012
Subject(s) - mesenchymal stem cell , stromal cell , adipose tissue , proinflammatory cytokine , chemokine , cytokine , immunology , microbiology and biotechnology , transforming growth factor , biology , cancer research , inflammation , endocrinology
This study analyzed the effect of transforming growth factor‐β1 (TGF‐β1) on the secretion of 80 cytokines/chemokines using an antibody array by adipose‐derived mesenchymal stromal cells. TGF‐β1 exposure modulated 8 chemokines and 18 cytokines, including TGF‐β1 and ‐β2, and other important cytokines involved in immunosuppression, allergic responses, and bone resorption.