Open AccessHealth Span‐Extending Activity of Human Amniotic Membrane‐ and Adipose Tissue‐Derived Stem Cells in F344 Rats
Author(s) -
Kim Dajeong,
Kyung Jangbeen,
Park Dongsun,
Choi Ehn-Kyoung,
Kim Kwang Sei,
Shin Kyungha,
Lee Hangyoung,
Shin Il Seob,
Kang Sung Keun,
Ra Jeong Chan,
Kim Yun-Bae
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0011
Subject(s) - stem cell , mesenchymal stem cell , transplantation , progenitor cell , biology , stem cell transplantation for articular cartilage repair , adult stem cell , wharton's jelly , stem cell therapy , amniotic epithelial cells , medicine , adipose tissue , physiology , microbiology and biotechnology , immunology , embryonic stem cell , endocrinology , biochemistry , gene
Human amniotic membrane‐derived mesenchymal stem cells (AMMSCs) or adipose tissue‐derived mesenchymal stem cells (ADMSCs) were intravenously transplanted into rats once a month. AMMSC and ADMSC transplantation improved cognitive and physical functions of naturally aging rats and extended life span, indicating that repeated transplantation of AMMSCs and ADMSCs elongate both health span and life span, which could be a starting point for antiaging or rejuvenation effects of allogeneic or autologous stem cells with minimum immune rejection.