Open AccessThe Therapeutic Potential of Human Umbilical Mesenchymal Stem Cells From Wharton's Jelly in the Treatment of Rat Peritoneal Dialysis‐Induced Fibrosis
Author(s) -
Fan Yu-Pei,
Hsia Ching-Chih,
Tseng Kuang-Wen,
Liao Chih-Kai,
Fu Tz-Win,
Ko Tsui-Ling,
Chiu Mei-Miao,
Shih Yang-Hsin,
Huang Pei-Yu,
Chiang Yi-Chia,
Yang Chih-Ching,
Fu Yu-Show
Publication year - 2016
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2015-0001
Subject(s) - peritoneal dialysis , peritoneum , medicine , fibrosis , mesenchymal stem cell , peritoneal cavity , intraperitoneal injection , mesothelial cell , wharton's jelly , pathology , andrology , surgery
Peritoneal fibrosis is a complication of continuous, ambulatory peritoneal dialysis in patients with end‐stage renal disease who are undergoing long‐term peritoneal dialysis. Intraperitoneal injection of human umbilical mesenchymal stem cells (HUMSCs) in rats ameliorated peritoneal dialysis/methylglyoxal‐induced abdominal cocoon formation, peritoneal fibrosis, inflammation, neoangiogenesis, and ultrafiltration failure.