Open AccessTransplantation of Epigenetically Modified Adult Cardiac c‐Kit+ Cells Retards Remodeling and Improves Cardiac Function in Ischemic Heart Failure Model
Author(s) -
Zakharova Liudmila,
Nural-Guvener Hikmet,
Feehery Lorraine,
Popovic-Sljukic Snjezana,
Gaballa Mohamed A.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0290
Subject(s) - cardiac function curve , heart failure , medicine , transplantation , myocardial infarction , ventricular remodeling , histone deacetylase , cardiology , biology , histone , biochemistry , gene
The cardiogenic potential of cardiac c‐Kit+ cells through class I histone deacetylase (HDAC) inhibition was augmented and their therapeutic potency in the chronic heart failure (CHF) animal model evaluated. The low cell engraftment suggests that paracrine effects might account for the beneficial effects of c‐Kit+ cells in CHF. Selective inhibition of class I HDACs induced expression of cardiac markers in c‐Kit+ cells and partially augmented their efficacy for CHF repair.