Open AccessPostinfarction Functional Recovery Driven by a Three‐Dimensional Engineered Fibrin Patch Composed of Human Umbilical Cord Blood‐Derived Mesenchymal Stem Cells
Author(s) -
Roura Santiago,
Soler-Botija Carolina,
Bagó Juli R.,
Llucià-Valldeperas Aida,
Férnandez Marco A.,
Gálvez-Montón Carolina,
Prat-Vidal Cristina,
Perea-Gil Isaac,
Blanco Jerónimo,
Bayes-Genis Antoni
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0259
Subject(s) - fibrin , mesenchymal stem cell , myocardial infarction , stem cell , umbilical cord , bioluminescence imaging , medicine , cardiology , regeneration (biology) , ventricular remodeling , biomedical engineering , pathology , anatomy , microbiology and biotechnology , immunology , biology , luciferase , cell culture , transfection , genetics
The ability of a three‐dimensional (3D) engineered fibrin patch with human umbilical cord blood‐derived mesenchymal stem cells (UCBMSCs) to induce recovery of cardiac function after myocardial infarction (MI) was investigated. The left ventricular ejection fraction and fractional shortening were improved in MI‐UCBMSC mice and markedly reduced in fibrin alone‐treated and untreated postinfarction control mice. A 3D engineered fibrin‐UCBMSC patch attenuated infarct‐derived cardiac dysfunction when transplanted locally over a myocardial wound.