Open AccessSystemically Delivered Adipose Stromal Vascular Fraction Cells Disseminate to Peripheral Artery Walls and Reduce Vasomotor Tone Through a CD11b + Cell‐Dependent Mechanism
Author(s) -
Morris Marvin E.,
Beare Jason E.,
Reed Robert M.,
Dale Jacob R.,
LeBlanc Amanda J.,
Kaufman Christina L.,
Zheng Huaiyu,
Ng Chin K.,
Williams Stuart K.,
Hoying James B.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0252
Subject(s) - stromal vascular fraction , adventitia , medicine , adipose tissue , artery , stromal cell , pathology , endocrinology
The hypothesis that autologous stromal vascular fraction (SVF) cells therapeutically modulate peripheral artery vasoactivity in syngeneic mouse models of small artery function was tested. Freshly isolated, adipose SVF cells promoted vasomotor relaxation in vasoactive arteries via a hydrogen peroxide‐dependent mechanism that required CD11b + cells (most likely macrophages). The intravenous delivery of this therapeutic cell preparation would significantly improve tissue perfusion, in particular, in disease with diffuse vascular involvement.