Open AccessThe Lymph Node as a New Site for Kidney Organogenesis
Author(s) -
Francipane Maria Giovanna,
Lagasse Eric
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0208
Subject(s) - biology , kidney , renal stem cell , kidney development , embryonic stem cell , transplantation , stem cell , organogenesis , population , pathology , lymph node , progenitor cell , microbiology and biotechnology , medicine , immunology , endocrinology , biochemistry , environmental health , gene
This study investigated whether the lymph node (LN) could support kidney organogenesis from mouse renal embryonic tissue. Findings indicate that the LN might be exploited as an in vivo platform for kidney development studies, as well as in vivo validation of the differentiation potential of candidate stem cells in regenerative nephrology. The LN might also provide an exclusive site for kidney organogenesis for therapeutic purposes.