Identification of Neurexophilin 3 as a Novel Supportive Factor for Survival of Induced Pluripotent Stem Cell‐Derived Dopaminergic Progenitors | Zendy

Nishimura Kaneyasu | Zendy; Murayama Shigeo | Zendy; Takahashi Jun | Zendy

Open Access

Identification of Neurexophilin 3 as a Novel Supportive Factor for Survival of Induced Pluripotent Stem Cell‐Derived Dopaminergic Progenitors

Author(s) -

Nishimura Kaneyasu,

Murayama Shigeo,

Takahashi Jun

Publication year - 2015

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2014-0197

Subject(s) - striatum , mptp , dopaminergic , tyrosine hydroxylase , induced pluripotent stem cell , progenitor cell , transplantation , biology , parkinson's disease , stem cell , dopamine , microbiology and biotechnology , medicine , endocrinology , embryonic stem cell , disease , biochemistry , gene

This study established an experimental strategy to identify effective factors for cell transplantation in Parkinson's disease (PD) based on comparison of several brain environments. Neurexophilin 3 was identified as a new supportive factor for cell transplantation and may be a useful biomarker for PD patients. These findings are expected to promote in vivo and in vitro applications of stem cell technology.

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