Open AccessIdentification of Neurexophilin 3 as a Novel Supportive Factor for Survival of Induced Pluripotent Stem Cell‐Derived Dopaminergic Progenitors
Author(s) -
Nishimura Kaneyasu,
Murayama Shigeo,
Takahashi Jun
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0197
Subject(s) - striatum , mptp , dopaminergic , tyrosine hydroxylase , induced pluripotent stem cell , progenitor cell , transplantation , biology , parkinson's disease , stem cell , dopamine , microbiology and biotechnology , medicine , endocrinology , embryonic stem cell , disease , biochemistry , gene
This study established an experimental strategy to identify effective factors for cell transplantation in Parkinson's disease (PD) based on comparison of several brain environments. Neurexophilin 3 was identified as a new supportive factor for cell transplantation and may be a useful biomarker for PD patients. These findings are expected to promote in vivo and in vitro applications of stem cell technology.