Open AccessAssessment of the Tumorigenic Potential of Spontaneously Immortalized and hTERT ‐Immortalized Cultured Dental Pulp Stem Cells
Author(s) -
Wilson Ryan,
Urraca Nora,
Skobowiat Cezary,
Hope Kevin A.,
Miravalle Leticia,
Chamberlin Reed,
Donaldson Martin,
Seagroves Tiffany N.,
Reiter Lawrence T.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0196
Subject(s) - immortalised cell line , dental pulp stem cells , telomerase reverse transcriptase , cell culture , biology , telomerase , stem cell , cancer research , microbiology and biotechnology , genetics , gene
This study demonstrated that immortalized dental pulp stem cells (DPSCs) do not form tumors in animals and that immortalized DPSCs can be differentiated into neurons in culture. These results lend support to the use of primary and immortalized DPSCs for future therapeutic approaches to treatment of neurobiological diseases.