Assessment of the Tumorigenic Potential of Spontaneously Immortalized and  hTERT ‐Immortalized Cultured Dental Pulp Stem Cells | Zendy

Wilson Ryan | Zendy; Urraca Nora | Zendy; Skobowiat Cezary | Zendy; Hope Kevin A. | Zendy; Miravalle Leticia | Zendy; Chamberlin Reed | Zendy; Donaldson Martin | Zendy; Seagroves Tiffany N. | Zendy; Reiter Lawrence T. | Zendy

Open Access

Assessment of the Tumorigenic Potential of Spontaneously Immortalized and hTERT ‐Immortalized Cultured Dental Pulp Stem Cells

Author(s) -

Wilson Ryan,

Urraca Nora,

Skobowiat Cezary,

Hope Kevin A.,

Miravalle Leticia,

Chamberlin Reed,

Donaldson Martin,

Seagroves Tiffany N.,

Reiter Lawrence T.

Publication year - 2015

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2014-0196

Subject(s) - dental pulp stem cells , immortalised cell line , stem cell , telomerase reverse transcriptase , biology , cell culture , microbiology and biotechnology , telomerase , genetics , gene

This study demonstrated that immortalized dental pulp stem cells (DPSCs) do not form tumors in animals and that immortalized DPSCs can be differentiated into neurons in culture. These results lend support to the use of primary and immortalized DPSCs for future therapeutic approaches to treatment of neurobiological diseases.

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