Open AccessSafety and Feasibility for Pediatric Cardiac Regeneration Using Epicardial Delivery of Autologous Umbilical Cord Blood‐Derived Mononuclear Cells Established in a Porcine Model System
Author(s) -
Cantero Peral Susana,
Burkhart Harold M.,
Oommen Saji,
Yamada Satsuki,
Nyberg Scott L.,
Li Xing,
O'Leary Patrick W.,
Terzic Andre,
Can Bryan C.,
Nelson Timothy J.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0195
Subject(s) - medicine , umbilical cord , perioperative , cell therapy , surgery , peripheral blood mononuclear cell , stem cell , immunology , biochemistry , chemistry , biology , in vitro , genetics
This study established a porcine pipeline to evaluate the feasibility and long‐term safety of autologous umbilical cord blood mononuclear cells (UCB‐MNCs) transplanted into the right ventricle (RV) of juvenile porcine hearts. The results show that autologous UCB‐MNCs can be safely collected and surgically delivered in a pediatric setting, establishing the foundation for cell‐based therapy directed at the RV of juvenile hearts and aims to accelerate cell‐based therapies toward clinical trials for congenital heart disease.