Open AccessRunx1t1 Regulates the Neuronal Differentiation of Radial Glial Cells From the Rat Hippocampus
Author(s) -
Linqing Zou,
Guohua Jin,
Haoming Li,
Xuelei Tao,
Jianbing Qin,
Meiling Tian
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0158
Subject(s) - neurogenesis , biology , corepressor , neuroscience , neural stem cell , microbiology and biotechnology , stem cell , genetics , gene expression , gene , psychological repression
Runx1t1 was knocked down in hippocampal radial glial cells (RGCs) with Runx1t1‐RNA interference using lentiviral vectors. Experimental evidence showed that decreased Runx1t1 expression reduced the neuronal differentiation of RGCs and increased Runx1t1 expression caused a greater number of RGCs to differentiate into neurons. Thus, Runx1t1 could be involved in the process through which RGCs differentiate into neurons.