Open AccessConcise Review: Engineering the Fusion of Cytokines for the Modulation of Immune Cellular Responses in Cancer and Autoimmune Disorders
Author(s) -
Ng Spencer,
Galipeau Jacques
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0145
Subject(s) - immune system , cytokine , immunology , cancer , immunotherapy , fusion protein , biology , interleukin , interleukin 2 , interleukin 15 , cancer research , genetics , recombinant dna , gene
The fusion of granulocyte‐macrophage colony‐stimulating factor to members of common γ‐chain interleukins results in the generation of novel proteins, termed GIFT fusokines, with unique signaling properties and unheralded biological effects that cannot be explained by the mere sum of their constituent moieties. This review examines the ways in which the GIFT fusokines are able to alter the immune response, particularly in disease states, with a special emphasis on how these novel molecules may be translated into effective therapies in the clinical setting.