Open AccessPeripheral Blood‐Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion in the Equine Model
Author(s) -
Bussche Leen,
Van de Walle Gerlinde R.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0138
Subject(s) - paracrine signalling , angiogenesis , stromal cell , mesenchymal stem cell , vascular endothelial growth factor , secretion , peripheral blood , stimulation , microbiology and biotechnology , vascular endothelial growth factor a , immunology , cancer research , medicine , biology , vegf receptors , endocrinology , receptor
The presence of angiogenic‐stimulating factors in conditioned medium (CM) of peripheral blood‐derived equine mesenchymal stromal cells (PB‐MSCs) was examined, and their in vitro effect on angiogenesis‐related endothelial cell (EC) behavior was studied. CM from PB‐MSCs contained significant levels of several proangiogenic factors and induced angiogenesis in equine vascular ECs, with enhanced EC network formation by increasing vascular endothelial growth factor‐A expression, an important angiogenesis stimulator.