Open AccessConcise Review: Modeling Multiple Sclerosis With Stem Cell Biological Platforms: Toward Functional Validation of Cellular and Molecular Phenotypes in Inflammation‐Induced Neurodegeneration
Author(s) -
Orack Joshua C.,
Deleidi Michela,
Pitt David,
Mahajan Kedar,
Nicholas Jacqueline A.,
Boster Aaron L.,
Racke Michael K.,
Comabella Manuel,
Watanabe Fumihiro,
Imitola Jaime
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0133
Subject(s) - neurodegeneration , reprogramming , multiple sclerosis , induced pluripotent stem cell , neuroscience , progenitor cell , stem cell , neural stem cell , mesenchymal stem cell , biology , cell therapy , neurogenesis , regenerative medicine , disease , medicine , cell , immunology , pathology , embryonic stem cell , microbiology and biotechnology , biochemistry , genetics , gene
This review discusses the application and challenges of somatic cell reprogramming and induced pluripotent stem cell technology technologies, including the generation of neurons, oligodendrocytes, and oligodendrocyte progenitor cells (OPCs) from patients and novel stem cell and OPC cellular arrays, in the discovery of new mechanistic insights and the future development of MS reparative therapies.