Open AccessConcise Review: Hematopoietic Stem Cell Aging and the Prospects for Rejuvenation
Author(s) -
Wahlestedt Martin,
Pronk Cornelis Jan,
Bryder David
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0132
Subject(s) - stem cell , biology , haematopoiesis , hematopoietic stem cell , stem cell theory of aging , myeloid , phenotype , senescence , progenitor cell , immunology , microbiology and biotechnology , genetics , stem cell factor , gene
Evidence has suggested that aging of various organs and cellular systems associates with a functional demise of tissue‐resident stem cell populations. DNA damage and/or altered transcriptional landscapes have been proposed to be major drivers of the hematopoietic stem cell aging state. Recent data suggest that stem cell aging phenotypes are characterized by some degree of reversibility, which suggests the possibility of rejuvenating, or at least dampening, stem cell aging phenotypes in the elderly for therapeutic benefit.