Open AccessFunctional Maintenance of Differentiated Embryoid Bodies in Microfluidic Systems: A Platform for Personalized Medicine
Author(s) -
Guven Sinan,
Lindsey Jennifer S.,
Poudel Ishwari,
Chinthala Sireesha,
Nickerson Michael D.,
Gerami-Naini Behzad,
Gurkan Umut A.,
Anchan Raymond M.,
Demirci Utkan
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0119
Subject(s) - embryoid body , aromatase , biology , hormone , cellular differentiation , estrogen receptor , sexual differentiation , induced pluripotent stem cell , medicine , microbiology and biotechnology , endocrinology , embryonic stem cell , breast cancer , cancer , biochemistry , gene
The utility and advantage of a microfluidic chip culture system to enhance the development of personalized, on‐demand, treatment modules using embryoid bodies (EBs) is demonstrated. Under microfluidic conditions, differentiated steroidogenic EBs continued to secrete estradiol and progesterone at physiologically relevant concentrations. These results present a platform for the development of a new therapeutic system for personalized medicine.