Osteogenic Differentiation of Human Amniotic Epithelial Cells and Its Application in Alveolar Defect Restoration | Zendy

Jiawen Si | Zendy; Jianjun Zhang | Zendy; Jiewen Dai | Zendy; Dedong Yu | Zendy; Hongbo Yu | Zendy; Jun Shi | Zendy; Xudong Wang | Zendy; Shen Steve G.F. | Zendy; Lihe Guo | Zendy

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Osteogenic Differentiation of Human Amniotic Epithelial Cells and Its Application in Alveolar Defect Restoration

Author(s) -

Jiawen Si,

Jianjun Zhang,

Jiewen Dai,

Dedong Yu,

Hongbo Yu,

Jun Shi,

Xudong Wang,

Shen Steve G.F.,

Lihe Guo

Publication year - 2014

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2014-0118

Subject(s) - osteopontin , mesenchymal stem cell , microbiology and biotechnology , chemistry , alkaline phosphatase , amniotic epithelial cells , runx2 , progenitor cell , regeneration (biology) , cellular differentiation , in vivo , tissue engineering , stem cell , in vitro , pathology , immunology , biology , osteoblast , biomedical engineering , adult stem cell , medicine , biochemistry , gene , enzyme

The in vitro osteogenic differentiation process and in vivo bone regenerative property of human amniotic epithelial cells (hAECs) were investigated. The results showed improved bone regeneration by direct participation and a reduced early host immune response. hAECs possess proper osteogenic differentiation potential, with a modulatory influence on early tissue remodeling, making these cells a potential source of progenitor cells for clinical restoration of the alveolar defect.

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