Open AccessOsteogenic Differentiation of Human Amniotic Epithelial Cells and Its Application in Alveolar Defect Restoration
Author(s) -
Jiawen Si,
Jianjun Zhang,
Jiewen Dai,
Dedong Yu,
Hongbo Yu,
Jun Shi,
Xudong Wang,
Shen Steve G.F.,
Lihe Guo
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0118
Subject(s) - microbiology and biotechnology , andrology , biology , medicine
The in vitro osteogenic differentiation process and in vivo bone regenerative property of human amniotic epithelial cells (hAECs) were investigated. The results showed improved bone regeneration by direct participation and a reduced early host immune response. hAECs possess proper osteogenic differentiation potential, with a modulatory influence on early tissue remodeling, making these cells a potential source of progenitor cells for clinical restoration of the alveolar defect.