Open AccessPutative Immunogenicity Expression Profiling Using Human Pluripotent Stem Cells and Derivatives
Author(s) -
Awe Jason P.,
Gschweng Eric H.,
Vega-Crespo Agustin,
Voutila Jon,
Williamson Mary H.,
Truong Brian,
Kohn Donald B.,
Kasahara Noriyuki,
Byrne James A.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0117
Subject(s) - induced pluripotent stem cell , immunogenicity , biology , immune system , embryonic stem cell , gene expression profiling , stem cell , transplantation , ectopic expression , microbiology and biotechnology , immunology , gene expression , gene , genetics , medicine , surgery
Correlative gene expression analysis of two putative mouse “immunogenicity” genes, ZG16 and HORMAD1 , was used to assay their human homologous expression levels in human pluripotent stem cells and their derivatives. We found that ZG16 expression is heterogeneous across multiple human embryonic stem cell and human induced pluripotent stem cell‐derived cell types. Neither of the previous immunogenicity‐associated genes in the mouse currently appears to be relevant in a human context.