Open AccessClinical Implication of Allogenic Implantation of Adipogenic Differentiated Adipose‐Derived Stem Cells
Author(s) -
Kim Inok,
Bang Sa Ik,
Lee Sung Koo,
Park Soo Young,
Kim Mihyung,
Ha Hunjoo
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0109
Subject(s) - adipogenesis , adipose tissue , immune system , major histocompatibility complex , stem cell , immunology , biology , microbiology and biotechnology , cancer research , endocrinology
The goal of this study was to investigate the immunological properties of adipogenic differentiated adipose‐derived stem cells (ASCs) to evaluate their suitability for allogenic applications, including in vitro, in vivo, and clinical applications, through comprehensive studies. The allogenic immune response of adipogenic differentiated ASCs was investigated by flow cytometry, mixed lymphocyte culture, and allogenic implantation. The results suggest that adipogenic differentiated ASCs can be used as a universal donor for soft‐tissue engineering in major histocompatibility complex‐mismatched recipients.