Clinical Implication of Allogenic Implantation of Adipogenic Differentiated Adipose‐Derived Stem Cells | Zendy

Kim Inok | Zendy; Bang Sa Ik | Zendy; Lee Sung Koo | Zendy; Park Soo Young | Zendy; Kim Mihyung | Zendy; Ha Hunjoo | Zendy

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Clinical Implication of Allogenic Implantation of Adipogenic Differentiated Adipose‐Derived Stem Cells

Author(s) -

Kim Inok,

Bang Sa Ik,

Lee Sung Koo,

Park Soo Young,

Kim Mihyung,

Ha Hunjoo

Publication year - 2014

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2014-0109

Subject(s) - adipogenesis , adipose tissue , immune system , stem cell , major histocompatibility complex , immunology , biology , cellular differentiation , microbiology and biotechnology , cancer research , endocrinology , biochemistry , gene

The goal of this study was to investigate the immunological properties of adipogenic differentiated adipose‐derived stem cells (ASCs) to evaluate their suitability for allogenic applications, including in vitro, in vivo, and clinical applications, through comprehensive studies. The allogenic immune response of adipogenic differentiated ASCs was investigated by flow cytometry, mixed lymphocyte culture, and allogenic implantation. The results suggest that adipogenic differentiated ASCs can be used as a universal donor for soft‐tissue engineering in major histocompatibility complex‐mismatched recipients.

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