Open AccessNG2+ Progenitors Derived From Embryonic Stem Cells Penetrate Glial Scar and Promote Axonal Outgrowth Into White Matter After Spinal Cord Injury
Author(s) -
Vadivelu Sudhakar,
Stewart Todd J.,
Qu Yun,
Horn Kevin,
Liu Su,
Li Qun,
Silver Jerry,
McDonald John W.
Publication year - 2015
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0107
Subject(s) - glial scar , chondroitin sulfate proteoglycan , microbiology and biotechnology , regeneration (biology) , embryonic stem cell , biology , stem cell , spinal cord , spinal cord injury , progenitor cell , neural stem cell , axon , anatomy , neuroscience , proteoglycan , extracellular matrix , biochemistry , gene
Embryonic stem (ES) cell‐derived neural lineage cells were transplanted into the spinal cord 9 days after injury. The results of this study provide the first evidence that cellular support for axonal outgrowth through the glial scar may be a property of the nerve glial antigen 2 (NG2)‐positive cell, suggesting that various cell types expressing NG2 might stimulate axonal growth even after the acute phase of spinal cord injury is over.