NG2+ Progenitors Derived From Embryonic Stem Cells Penetrate Glial Scar and Promote Axonal Outgrowth Into White Matter After Spinal Cord Injury | Zendy

Vadivelu Sudhakar | Zendy; Stewart Todd J. | Zendy; Qu Yun | Zendy; Horn Kevin | Zendy; Liu Su | Zendy; Li Qun | Zendy; Silver Jerry | Zendy; McDonald John W. | Zendy

Open Access

NG2+ Progenitors Derived From Embryonic Stem Cells Penetrate Glial Scar and Promote Axonal Outgrowth Into White Matter After Spinal Cord Injury

Author(s) -

Vadivelu Sudhakar,

Stewart Todd J.,

Qu Yun,

Horn Kevin,

Liu Su,

Li Qun,

Silver Jerry,

McDonald John W.

Publication year - 2015

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2014-0107

Subject(s) - glial scar , chondroitin sulfate proteoglycan , microbiology and biotechnology , embryonic stem cell , regeneration (biology) , biology , stem cell , spinal cord , spinal cord injury , neural stem cell , progenitor cell , axon , neuroscience , anatomy , proteoglycan , extracellular matrix , biochemistry , gene

Embryonic stem (ES) cell‐derived neural lineage cells were transplanted into the spinal cord 9 days after injury. The results of this study provide the first evidence that cellular support for axonal outgrowth through the glial scar may be a property of the nerve glial antigen 2 (NG2)‐positive cell, suggesting that various cell types expressing NG2 might stimulate axonal growth even after the acute phase of spinal cord injury is over.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research