Open AccessIntercellular Cooperation and Competition in Brain Cancers: Lessons From Drosophila and Human Studies
Author(s) -
Waghmare Indrayani,
Roebke Austin,
Minata Mutsuko,
Kango-Singh Madhuri,
Nakano Ichiro
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0086
Subject(s) - biology , wnt signaling pathway , cancer stem cell , cancer research , cancer , cancer cell , stem cell , phenotype , context (archaeology) , glioma , cell growth , apoptosis , signal transduction , microbiology and biotechnology , genetics , gene , paleontology
Glioblastoma (GBM) is a primary brain cancer with an extremely poor prognosis. Recent studies in Drosophila and mammalian models (e.g., xenografts of human cancer cells into small animals) are summarized to elucidate the intercellular interactions between apoptosis‐prone cancer cells and hyperproliferative cancer cells. These evolving investigations will yield insights on molecular signaling interactions in the context of post‐therapeutic phenotypic changes in human cancers.