Open AccessTesticular Niche Required for Human Spermatogonial Stem Cell Expansion
Author(s) -
Smith James F.,
Yango Pamela,
Altman Eran,
Choudhry Shweta,
Poelzl Andrea,
Zamah Alberuni M.,
Rosen Mitchell,
Klatsky Peter C.,
Tran Nam D.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0045
Subject(s) - biology , stromal cell , mesenchymal stem cell , somatic cell , stem cell , microbiology and biotechnology , cell sorting , population , immunology , andrology , cancer research , genetics , flow cytometry , medicine , gene , environmental health
This study characterizes the cellular niche required for the expansion of human spermatogonial stem cells (SSCs), provides strong evidence supporting specific extracellular markers that define a testicular cell population highly enriched for human SSCs, and characterizes a novel testicular multipotent stromal cell population essential for SSC expansion. The results of this study are very important to understanding how human SSCs can be grown and expanded successfully in vitro for future therapeutic applications.