Laminin‐111 Improves Skeletal Muscle Stem Cell Quantity and Function Following Eccentric Exercise | Zendy

Zou Kai | Zendy; De Lisio Michael | Zendy; Huntsman Heather D. | Zendy; Pincu Yair | Zendy; Mahmassani Ziad | Zendy; Miller Matthew | Zendy; Olatunbosun Dami | Zendy; Jensen Tor | Zendy; Boppart Marni D. | Zendy

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Laminin‐111 Improves Skeletal Muscle Stem Cell Quantity and Function Following Eccentric Exercise

Author(s) -

Zou Kai,

De Lisio Michael,

Huntsman Heather D.,

Pincu Yair,

Mahmassani Ziad,

Miller Matthew,

Olatunbosun Dami,

Jensen Tor,

Boppart Marni D.

Publication year - 2014

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2014-0044

Subject(s) - eccentric exercise , skeletal muscle , stem cell , eccentric , microbiology and biotechnology , myocyte , laminin , function (biology) , chemistry , medicine , biology , anatomy , endocrinology , muscle damage , physics , extracellular matrix , quantum mechanics

The study's purpose was to determine the extent to which laminin‐111 (LM‐111) can alter stem cell quantity following eccentric exercise‐induced damage in mice. Although mesenchymal stem cell (MSC) percentage and number were not altered, MSC proinflammatory gene expression was decreased, and hepatocyte growth factor gene expression was increased, suggesting that LM‐111 supplementation provides a viable solution for increasing skeletal muscle stem cell number and/or function, allowing for improvements in the regenerative response to exercise.

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