Open AccessLaminin‐111 Improves Skeletal Muscle Stem Cell Quantity and Function Following Eccentric Exercise
Author(s) -
Zou Kai,
De Lisio Michael,
Huntsman Heather D.,
Pincu Yair,
Mahmassani Ziad,
Miller Matthew,
Olatunbosun Dami,
Jensen Tor,
Boppart Marni D.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0044
Subject(s) - skeletal muscle , extracellular matrix , biology , mesenchymal stem cell , stem cell , myosin , laminin , endocrinology , medicine , microbiology and biotechnology , andrology , chemistry
The study's purpose was to determine the extent to which laminin‐111 (LM‐111) can alter stem cell quantity following eccentric exercise‐induced damage in mice. Although mesenchymal stem cell (MSC) percentage and number were not altered, MSC proinflammatory gene expression was decreased, and hepatocyte growth factor gene expression was increased, suggesting that LM‐111 supplementation provides a viable solution for increasing skeletal muscle stem cell number and/or function, allowing for improvements in the regenerative response to exercise.