Open AccessVery Late Antigen‐5 Facilitates Stromal Progenitor Cell Differentiation Into Myofibroblast
Author(s) -
Sen Namita,
Weingarten Mark,
Peter Yakov
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0014
Subject(s) - myofibroblast , stromal cell , progenitor cell , biology , microbiology and biotechnology , mesenchymal stem cell , cellular differentiation , fibroblast , population , stem cell , immunology , pathology , fibrosis , cancer research , cell culture , medicine , genetics , environmental health , gene
The role of an early stromal progenitor cell (SPC) on the fibrotic process was investigated by monitoring fibroblast development from a free‐floating anchorage‐independent cell progenitor population. The inability of SPCs to revert to the free‐floating state confirmed cell differentiation. SPC derivation into stromal tissue in vitro and in vivo and that mesenchymal stem/stromal cell and fibroblast lineages share a common ancestor could potentially lead to personalized antifibrotic therapies.