Open AccessHierarchy of Breast Cancer Cells: Key to Reverse Dormancy for Therapeutic Intervention
Author(s) -
Bliss Sarah A.,
Greco Steven J.,
Rameshwar Pranela
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0013
Subject(s) - stem cell , cancer stem cell , bone marrow , dormancy , haematopoiesis , cancer cell , breast cancer , cancer research , cancer , biology , medicine , immunology , microbiology and biotechnology , botany , germination
This paper discusses how research studies could bring an understanding of the cellular and molecular interactions between the cancer stem cells and cells within the bone marrow microenvironment. This will allow for intervention to reverse dormancy for targeted treatment. The treatment will require studies within the normal organ functions to ensure treatment without toxicity.