Open AccessMultipotent Mesenchymal Stromal Cells Synergize With Costimulation Blockade in the Inhibition of Immune Responses and the Induction of Foxp3 + Regulatory T Cells
Author(s) -
Takahashi Tohru,
Tibell Annika,
Ljung Karin,
Saito Yu,
Gronlund Anna,
Osterholm Cecilia,
Holgersson Jan,
Lundgren Torbjörn,
Ericzon Bo-Göran,
Corbascio Matthias,
Kumagai-Braesch Makiko
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2014-0012
Subject(s) - foxp3 , mesenchymal stem cell , immunology , immune system , blockade , cell therapy , regulatory t cell , t cell , immune tolerance , stromal cell , splenocyte , medicine , cancer research , biology , microbiology and biotechnology , il 2 receptor , stem cell , receptor
Multipotent mesenchymal stromal cells (MSCs) from C57BL/6 (H2 b ) mice were infused with fully major histocompatibility complex‐mismatched Balb/c (H2 d ) allogeneic islets into the portal vein of diabetic C57BL/6 (H2 b ) mice, which were treated with costimulation blockade for 10 days. Their livers contained large numbers of islets surrounded by Foxp3 + regulatory T cells. MSC infusion and costimulation blockade have complementary immune‐modulating effects that can be used for a broad number of applications.