Multipotent Mesenchymal Stromal Cells Synergize With Costimulation Blockade in the Inhibition of Immune Responses and the Induction of Foxp3 +  Regulatory T Cells | Zendy

Takahashi Tohru | Zendy; Tibell Annika | Zendy; Ljung Karin | Zendy; Saito Yu | Zendy; Gronlund Anna | Zendy; Osterholm Cecilia | Zendy; Holgersson Jan | Zendy; Lundgren Torbjörn | Zendy; Ericzon Bo-Göran | Zendy; Corbascio Matthias | Zendy; Kumagai-Braesch Makiko | Zendy

Open Access

Multipotent Mesenchymal Stromal Cells Synergize With Costimulation Blockade in the Inhibition of Immune Responses and the Induction of Foxp3 + Regulatory T Cells

Author(s) -

Takahashi Tohru,

Tibell Annika,

Ljung Karin,

Saito Yu,

Gronlund Anna,

Osterholm Cecilia,

Holgersson Jan,

Lundgren Torbjörn,

Ericzon Bo-Göran,

Corbascio Matthias,

Kumagai-Braesch Makiko

Publication year - 2014

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2014-0012

Subject(s) - foxp3 , mesenchymal stem cell , immunology , immune system , blockade , cell therapy , regulatory t cell , t cell , immune tolerance , stromal cell , splenocyte , medicine , cancer research , biology , microbiology and biotechnology , il 2 receptor , stem cell , receptor

Multipotent mesenchymal stromal cells (MSCs) from C57BL/6 (H2 b ) mice were infused with fully major histocompatibility complex‐mismatched Balb/c (H2 d ) allogeneic islets into the portal vein of diabetic C57BL/6 (H2 b ) mice, which were treated with costimulation blockade for 10 days. Their livers contained large numbers of islets surrounded by Foxp3 + regulatory T cells. MSC infusion and costimulation blockade have complementary immune‐modulating effects that can be used for a broad number of applications.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research