Open AccessTargeting Cancer Stem Cell Plasticity Through Modulation of Epidermal Growth Factor and Insulin‐Like Growth Factor Receptor Signaling in Head and Neck Squamous Cell Cancer
Author(s) -
Leong Hui Sun,
Chong Fui Teen,
Sew Pui Hoon,
Lau Dawn P.,
Wong Bernice H.,
Teh Bin-Tean,
Tan Daniel S.W.,
Iyer N. Gopalakrishna
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0214
Subject(s) - cancer stem cell , homeobox protein nanog , epidermal growth factor receptor , stem cell , biology , cancer research , epidermal growth factor , stem cell marker , growth factor receptor , microbiology and biotechnology , cell culture , cancer , signal transduction , embryonic stem cell , induced pluripotent stem cell , genetics , gene
An in vitro system that recapitulates stem cell plasticity in head and neck squamous cell cancers (HNSCCs) was established and the factors that play a role in the maintenance and repopulation of cancer stem cells (CSCs) were identified. The results show that HNSCC CSCs exhibit plasticity, with maintenance of the stem cell fraction dependent on the epidermal growth factor receptor and insulin‐like growth factor‐1 receptor pathways and potentially amenable to targeted therapeutics.