Open AccessIn Vivo Hypobaric Hypoxia Performed During the Remodeling Process Accelerates Bone Healing in Mice
Author(s) -
Durand Marjorie,
Collombet Jean-Marc,
Frasca Sophie,
Begot Laurent,
Lataillade Jean-Jacques,
Le Bousse-Kerdilès Marie-Caroline,
Holy Xavier
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0209
Subject(s) - bone healing , hindlimb , femur , medicine , mesenchymal stem cell , hypoxia (environmental) , wound healing , bone marrow , surgery , pathology , anatomy , chemistry , organic chemistry , oxygen
The authors investigated the effects of respiratory hypobaric hypoxia on femoral bone defect repair in mice because hypoxia is believed to influence both mesenchymal stromal cell and hematopoietic stem cell mobilization, a process involved in bone healing. The results indicated that delayed hypoxia applied during the remodeling process enhanced bone‐healing efficiency. Consequently, a specific therapeutic window for hypoxia might ensure an enhanced bone‐healing process.