Open AccessHuman Neural Stem Cells Survive Long Term in the Midbrain of Dopamine‐Depleted Monkeys After GDNF Overexpression and Project Neurites Toward an Appropriate Target
Author(s) -
Wakeman Dustin R.,
Redmond D. Eugene,
Dodiya Hemraj B.,
Sladek John R.,
Leranth Csaba,
Teng Yang D.,
Samulski R. Jude,
Snyder Evan Y.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0208
Subject(s) - glial cell line derived neurotrophic factor , substantia nigra , neurite , neuroscience , striatum , biology , neural stem cell , neurotrophic factors , dopamine , stem cell , transplantation , tyrosine hydroxylase , microbiology and biotechnology , dopaminergic , medicine , receptor , biochemistry , in vitro
The authors tested whether overexpression of glial cell‐derived neurotrophic factor transduced by adeno‐associated virus serotype 5 and injected into the dopamine‐depleted primate striatum could enhance graft integration and improve dopamine differentiation of multipotent donor human fetal neural stem cells injected at the same time into the substantia nigra. Results suggest that transplantation could lead to reconstruction of some portion of the nigrostriatal pathway and prove beneficial for the parkinsonian condition.