Open AccessCholesterol and Hematopoietic Stem Cells: Inflammatory Mediators of Atherosclerosis
Author(s) -
Lang Jennifer K.,
Cimato Thomas R.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0205
Subject(s) - haematopoiesis , stem cell , inflammation , cholesterol , chemistry , microbiology and biotechnology , cancer research , immunology , biology , biochemistry
Recent findings have provided new insight into the interaction among hematopoietic stem cells (HSPCs), cholesterol, and atherosclerosis. The authors review studies in mice and consider the connection in humans between cholesterol and HSPCs. Recent studies represent an important avenue to determine whether the biology of humans is the same and whether antagonism of HSPC mobilization and differentiation in response to cholesterol is of benefit for prevention and regression of atherosclerosis.