Open AccessConcise Review: Optimizing Expansion of Bone Marrow Mesenchymal Stem/Stromal Cells for Clinical Applications
Author(s) -
Hoch Allison I.,
Leach J. Kent
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0196
Subject(s) - mesenchymal stem cell , progenitor cell , bone marrow , stem cell , haematopoiesis , biology , stromal cell , regenerative medicine , potency , immunology , microbiology and biotechnology , cancer research , in vitro , biochemistry
During two‐dimensional expansion to achieve a clinically relevant number of cells, mesenchymal stem/stromal cells (MSCs) exhibit profound degeneration in progenitor potency. To harness the robust therapeutic potential of MSCs, a consistent, rapid, and minimally detrimental expansion method is necessary. This review explores how modulations in the two‐dimensional paradigm affect MSC progenitor properties and highlights recent efforts in alternative expansion techniques.