Concise Review: Optimizing Expansion of Bone Marrow Mesenchymal Stem/Stromal Cells for Clinical Applications | Zendy

Hoch Allison I. | Zendy; Leach J. Kent | Zendy

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Concise Review: Optimizing Expansion of Bone Marrow Mesenchymal Stem/Stromal Cells for Clinical Applications

Author(s) -

Hoch Allison I.,

Leach J. Kent

Publication year - 2014

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2013-0196

Subject(s) - mesenchymal stem cell , progenitor cell , bone marrow , stem cell , haematopoiesis , biology , stromal cell , regenerative medicine , immunology , potency , microbiology and biotechnology , cancer research , in vitro , biochemistry

During two‐dimensional expansion to achieve a clinically relevant number of cells, mesenchymal stem/stromal cells (MSCs) exhibit profound degeneration in progenitor potency. To harness the robust therapeutic potential of MSCs, a consistent, rapid, and minimally detrimental expansion method is necessary. This review explores how modulations in the two‐dimensional paradigm affect MSC progenitor properties and highlights recent efforts in alternative expansion techniques.

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