Open AccessAmniotic Fluid‐Derived Mesenchymal Stem Cells Prevent Fibrosis and Preserve Renal Function in a Preclinical Porcine Model of Kidney Transplantation
Author(s) -
Baulier Edouard,
Favreau Frederic,
Le Corf Amélie,
Jayle Christophe,
Schneider Fabrice,
Goujon Jean-Michel,
Feraud Olivier,
Bennaceur-Griscelli Annelise,
Hauet Thierry,
Turhan Ali G.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0186
Subject(s) - mesenchymal stem cell , renal stem cell , transplantation , stem cell , medicine , amniotic stem cells , amniotic epithelial cells , fibrosis , amniotic fluid , stem cell therapy , regenerative medicine , stem cell transplantation for articular cartilage repair , cell therapy , pathology , cancer research , adult stem cell , immunology , biology , microbiology and biotechnology , cellular differentiation , progenitor cell , fetus , pregnancy , biochemistry , genetics , gene
This study of the efficiency and the safety of amniotic fluid‐derived mesenchymal stem cell infusion in a preclinical porcine model of renal autotransplantation showed improved glomerular and tubular functions, leading to full renal function recovery and abrogated fibrosis development at 3 months. The highly translational porcine model used for this study is a powerful tool to assess safety and feasibility of stem cell‐based therapies in the field of solid organ transplantation.