Open AccessPorcine Skeletal Muscle‐Derived Multipotent PW1 pos /Pax7 neg Interstitial Cells: Isolation, Characterization, and Long‐Term Culture
Author(s) -
Lewis Fiona C.,
Henning Beverley J.,
Marazzi Giovanna,
Sassoon David,
Ellison Georgina M.,
Nadal-Ginard Bernardo
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0174
Subject(s) - skeletal muscle , progenitor cell , microbiology and biotechnology , myogenesis , biology , multipotent stem cell , stem cell , myocyte , regeneration (biology) , population , anatomy , medicine , environmental health
This study demonstrates, in an animal model with size and physiology extrapolatable to the human, that porcine skeletal muscle‐derived PW1 pos /Pax7 neg interstitial progenitor cells are a source of stem/progenitor cells. These findings open new avenues for a variety of solid tissue engineering and regeneration using a single multipotent stem cell type isolated from an easily accessible source such as skeletal muscle.