Open AccessA Niche‐Like Culture System Allowing the Maintenance of Primary Human Acute Myeloid Leukemia‐Initiating Cells: A New Tool to Decipher Their Chemoresistance and Self‐Renewal Mechanisms
Author(s) -
Griessinger Emmanuel,
Anjos-Afonso Fernando,
Pizzitola Irene,
Rouault-Pierre Kevin,
Vargaftig Jacques,
Taussig David,
Gribben John,
Lassailly François,
Bonnet Dominique
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0166
Subject(s) - myeloid leukemia , cytarabine , leukemia , cancer research , xenotransplantation , stromal cell , biology , bone marrow , myeloid , transplantation , immunology , medicine
This paper presents a culture system that can be used as an in vitro surrogate for xenotransplantation and that has the potential to dramatically increase the throughput of the investigation of leukemia‐initiating cells, providing the means to identify and target the functionality of the different signaling pathways involved in the maintenance and resistance of leukemia‐initiating cells to improve acute myeloid leukemia treatments.