Open AccessFunctional Outcome After Anal Sphincter Injury and Treatment With Mesenchymal Stem Cells
Author(s) -
Salcedo Levilester,
Penn Marc,
Damaser Margot,
Balog Brian,
Zutshi Massarat
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0157
Subject(s) - external anal sphincter , medicine , saline , sphincter , urology , mesenchymal stem cell , anal sphincter , surgery , anal canal , anesthesia , rectum , pathology
An animal model of mesenchymal stem cell (MSC) treatment in anal sphincter injury was studied. Results show that a single i.m. treatment with MSCs after injury resulted in increased anal pressures similar to those of serial i.v. injections, and these pressures were sustained 5 weeks after injection. Given that MSCs delivered i.m. or i.v. resulted in functional recovery, the i.m. route may be preferable as fewer cells seem to be needed.