Open AccessGene Profiling of Human Induced Pluripotent Stem Cell‐Derived Astrocyte Progenitors Following Spinal Cord Engraftment
Author(s) -
Haidet-Phillips Amanda M.,
Roybon Laurent,
Gross Sarah K.,
Tuteja Alisha,
Donnelly Christopher J.,
Richard Jean-Philippe,
Ko Myungsung,
Sherman Alex,
Eggan Kevin,
Henderson Christopher E.,
Maragakis Nicholas J.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0153
Subject(s) - astrocyte , induced pluripotent stem cell , progenitor cell , embryonic stem cell , biology , transplantation , stem cell , neural stem cell , microbiology and biotechnology , immunology , neuroscience , medicine , central nervous system , gene , genetics
This study investigated whether human induced pluripotent stem cell (hiPSC)‐derived astrocyte progenitors could be engrafted to the rodent spinal cord and how the characteristics of these cells changed. Results show that human embryonic stem cell‐ and hiPSC‐derived astrocyte progenitors survive long‐term after spinal cord engraftment and differentiate to astrocytes in vivo with few cells from other lineages present.