Open AccessIntrastriatal Transplantation of Adenovirus‐Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington's Disease
Author(s) -
Fink Kyle D.,
Crane Andrew T.,
Lévêque Xavier,
Dues Dylan J.,
Huffman Lucas D.,
Moore Allison C.,
Story Darren T.,
DeJonge Rachel E.,
Antcliff Aaron,
Starski Phillip A.,
Lu Ming,
Lescaudron Laurent,
Rossignol Julien,
Dunbar Gary L.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0151
Subject(s) - induced pluripotent stem cell , transplantation , striatum , neuroscience , biology , huntington's disease , stem cell , pathology , medicine , disease , embryonic stem cell , dopamine , microbiology and biotechnology , biochemistry , gene
Induced pluripotent stem cells (iPSCs) show considerable promise for cell replacement therapies for Huntington's disease (HD). Results suggest that transplantation of adenovirus‐generated iPSCs may provide a potential avenue for therapeutic treatment of HD.