Open AccessAntitumor Effects of CD40 Ligand‐Expressing Endothelial Progenitor Cells Derived From Human Induced Pluripotent Stem Cells in a Metastatic Breast Cancer Model
Author(s) -
Purwanti Yovita Ida,
Chen Can,
Lam Dang Hoang,
Wu Chunxiao,
Zeng Jieming,
Fan Weimin,
Wang Shu
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0140
Subject(s) - cancer research , progenitor cell , induced pluripotent stem cell , cancer stem cell , stem cell , cd34 , metastasis , cancer , medicine , biology , immunology , embryonic stem cell , microbiology and biotechnology , biochemistry , gene
Endothelial progenitor cells (EPCs) are attractive as cellular vehicles for targeted cancer gene therapy. An embryoid body formation method was used to derive CD133 + CD34 + EPCs from human induced pluripotent stem (iPS) cells. The findings suggest that human iPS cell‐derived EPCs have the potential to serve as tumor‐targeted cellular vehicles for anticancer gene therapy.