Antitumor Effects of CD40 Ligand‐Expressing Endothelial Progenitor Cells Derived From Human Induced Pluripotent Stem Cells in a Metastatic Breast Cancer Model | Zendy

Purwanti Yovita Ida | Zendy; Chen Can | Zendy; Lam Dang Hoang | Zendy; Wu Chunxiao | Zendy; Zeng Jieming | Zendy; Fan Weimin | Zendy; Wang Shu | Zendy

Open Access

Antitumor Effects of CD40 Ligand‐Expressing Endothelial Progenitor Cells Derived From Human Induced Pluripotent Stem Cells in a Metastatic Breast Cancer Model

Author(s) -

Purwanti Yovita Ida,

Chen Can,

Lam Dang Hoang,

Wu Chunxiao,

Zeng Jieming,

Fan Weimin,

Wang Shu

Publication year - 2014

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2013-0140

Subject(s) - progenitor cell , induced pluripotent stem cell , cancer research , stem cell , cancer stem cell , cd40 , biology , progenitor , endothelial stem cell , microbiology and biotechnology , cytotoxic t cell , embryonic stem cell , in vitro , genetics , gene

Endothelial progenitor cells (EPCs) are attractive as cellular vehicles for targeted cancer gene therapy. An embryoid body formation method was used to derive CD133 + CD34 + EPCs from human induced pluripotent stem (iPS) cells. The findings suggest that human iPS cell‐derived EPCs have the potential to serve as tumor‐targeted cellular vehicles for anticancer gene therapy.

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