Induction of Human Embryonic and Induced Pluripotent Stem Cells Into Urothelium | Zendy

Osborn Stephanie L. | Zendy; Thangappan Ravikumar | Zendy; Luria Ayala | Zendy; Lee Justin H. | Zendy; Nolta Jan | Zendy; Kurzrock Eric A. | Zendy

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Induction of Human Embryonic and Induced Pluripotent Stem Cells Into Urothelium

Author(s) -

Osborn Stephanie L.,

Thangappan Ravikumar,

Luria Ayala,

Lee Justin H.,

Nolta Jan,

Kurzrock Eric A.

Publication year - 2014

Publication title -

stem cells translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.781

H-Index - 71

eISSN - 2157-6580

pISSN - 2157-6564

DOI - 10.5966/sctm.2013-0131

Subject(s) - urothelium , embryonic stem cell , induced pluripotent stem cell , stem cell , microbiology and biotechnology , biology , genetics , anatomy , gene , urinary system

The current study demonstrates that derivation of urothelium from human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) can be sufficiently accomplished in vitro in the absence of matrices, cell contact, or adult cell signaling and that the induction process appears to mimic normal differentiation. The ability to derive urothelium from nonautologous sources holds important implications for the bioengineering of bladder tissue for patients requiring urologic reconstruction.

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