Open AccessInduction of Human Embryonic and Induced Pluripotent Stem Cells Into Urothelium
Author(s) -
Osborn Stephanie L.,
Thangappan Ravikumar,
Luria Ayala,
Lee Justin H.,
Nolta Jan,
Kurzrock Eric A.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0131
Subject(s) - urothelium , embryonic stem cell , microbiology and biotechnology , induced pluripotent stem cell , biology , urothelial cell , stem cell , progenitor cell , cellular differentiation , regenerative medicine , directed differentiation , anatomy , genetics , urinary system , gene
The current study demonstrates that derivation of urothelium from human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) can be sufficiently accomplished in vitro in the absence of matrices, cell contact, or adult cell signaling and that the induction process appears to mimic normal differentiation. The ability to derive urothelium from nonautologous sources holds important implications for the bioengineering of bladder tissue for patients requiring urologic reconstruction.