Open AccessExpansive Generation of Functional Airway Epithelium From Human Embryonic Stem Cells
Author(s) -
McIntyre Brendan A.S.,
Alev Cantas,
Mechael Rami,
Salci Kyle R.,
Lee Jung Bok,
Fiebig-Comyn Aline,
Guezguez Borhane,
Wu Yuping,
Sheng Guojun,
Bhatia Mickie
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0119
Subject(s) - progenitor cell , embryonic stem cell , biology , microbiology and biotechnology , stem cell , respiratory epithelium , lung , immunology , cellular differentiation , anatomy , medicine , respiratory system , biochemistry , gene
This study revealed the potential of human embryonic stem cells (hESCs) to produce multipotent lung progenitors using a combined growth factor and physical culture approach. This approach allowed in vivo assessment, which demonstrated that only fully differentiated hESC‐derived airway cells were retained in the distal airway, where they aided in physiological recovery in immunocompromised mice receiving airway injury. This study provides a basis for translational applications of hESCs for lung diseases.