Open AccessPre‐ and Postnatal Transplantation of Fetal Mesenchymal Stem Cells in Osteogenesis Imperfecta: A Two‐Center Experience
Author(s) -
Götherström Cecilia,
Westgren Magnus,
Shaw S.W. Steven,
Åström Eva,
Biswas Arijit,
Byers Peter H.,
Mattar Citra N.Z.,
Graham Gail E.,
Taslimi Jahan,
Ewald Uwe,
Fisk Nicholas M.,
Yeoh Allen E.J.,
Lin Ju-Li,
Cheng Po-Jen,
Choolani Mahesh,
Le Blanc Katarina,
Chan Jerry K.Y.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0090
Subject(s) - medicine , osteogenesis imperfecta , transplantation , mesenchymal stem cell , fetus , surgery , pregnancy , pediatrics , pathology , biology , genetics
This study reports the clinical course of two patients with osteogenesis imperfecta who received prenatal human fetal mesenchymal stem cell (MSC) transplantation and postnatal boosting with same‐donor MSCs. Findings suggest that prenatal transplantation of allogeneic human fetal MSCs in osteogenesis imperfecta appears safe and is of likely clinical benefit and that retransplantation with same‐donor cells is feasible. Further studies are required.