Open AccessSox2 Suppression by miR‐21 Governs Human Mesenchymal Stem Cell Properties
Author(s) -
Trohatou Ourania,
Zagoura Dimitra,
Bitsika Vasiliki,
Pappa Kalliopi I.,
Antsaklis Aristidis,
Anagnou Nicholas P.,
Roubelakis Maria G.
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0081
Subject(s) - mesenchymal stem cell , sox2 , clonogenic assay , stem cell , microbiology and biotechnology , biology , adipogenesis , chondrogenesis , multipotent stem cell , microrna , population , stem cell transplantation for articular cartilage repair , adult stem cell , immunology , cancer research , endothelial stem cell , embryonic stem cell , cell , progenitor cell , medicine , genetics , in vitro , environmental health , gene
The miRNA profile of mesenchymal stem cells (MSCs) derived from amniotic fluid, bone marrow (BM), and umbilical cord blood was analyzed. Initially, 67 different miRNAs were identified that were expressed in all three types of MSCs but at different levels, depending on the source. A more detailed analysis revealed that miR‐21 was expressed at higher levels in RS‐AF‐MSCs and BM‐MSCs compared with SS‐AF‐MSCs. Findings suggest that miR‐21 might function by regulating Sox2 expression in human MSCs and might also act as a key molecule determining MSC proliferation and differentiation.