Open AccessDelivery of Differentiation Factors by Mesoporous Silica Particles Assists Advanced Differentiation of Transplanted Murine Embryonic Stem Cells
Author(s) -
Garcia-Bennett Alfonso E.,
Kozhevnikova Mariya,
König Niclas,
Zhou Chunfang,
Leao Richardson,
Knöpfel Thomas,
Pankratova Stanislava,
Trolle Carl,
Berezin Vladimir,
Bock Elisabeth,
Aldskogius Håkan,
Kozlova Ele.
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0072
Subject(s) - embryonic stem cell , microbiology and biotechnology , stem cell , cellular differentiation , mesoporous silica , biology , chemistry , mesoporous material , biochemistry , gene , catalysis
This study developed a novel technological approach for the local delivery of exogenous trophic factor mimetics to transplanted cells using specifically designed silica nanoporous particles. This is potentially a versatile and widely applicable strategy for the efficient differentiation and functional integration of stem cell derivatives upon transplantation, and it can serve as a foundation for improving stem cell‐based neuroregenerative protocols.