Open AccessConcise Review: Ex Vivo Expansion of Cord Blood‐Derived Hematopoietic Stem and Progenitor Cells: Basic Principles, Experimental Approaches, and Impact in Regenerative Medicine
Author(s) -
Flores-Guzmán Patricia,
Fernández-Sánchez Verónica,
Mayani Hector
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0071
Subject(s) - progenitor cell , regenerative medicine , haematopoiesis , stem cell , ex vivo , mesenchymal stem cell , microbiology and biotechnology , immunology , biology , stromal cell , cord blood , cancer research , in vivo
This review surveys current progress toward the ex vivo expansion of human umbilical cord blood‐derived hematopoietic stem cells (HSCs) and hematopoietic progenitor cells. Recent studies suggest that HSCs may also give rise to nonhematopoietic cells; this plasticity and the possibility of producing nonhematopoietic cells at the clinical scale could bring new alternatives for the treatment of neural, metabolic, orthopedic, cardiac, and neoplastic disorders.