Open AccessHuman Dendritic Cells Derived From Embryonic Stem Cells Stably Modified With CD1d Efficiently Stimulate Antitumor Invariant Natural Killer T Cell Response
Author(s) -
Zeng Jieming,
Wang Shu
Publication year - 2014
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0070
Subject(s) - cd1d , embryonic stem cell , biology , microbiology and biotechnology , cancer immunotherapy , natural killer t cell , stem cell , cell culture , immunotherapy , dendritic cell , immunology , cancer research , immune system , t cell , gene , genetics
A current strategy to harness invariant natural killer T (iNKT) cells for cancer treatment is endogenous iNKT cell activation using patient‐derived dendritic cells (DCs). However, the limited number and functional defects of patient DCs are still the major challenges for this therapeutic approach. In this study, we investigated whether human embryonic stem cells (hESCs) with ectopically expressed CD1d gene could be exploited to address this issue.