Open AccessEnhancing In Vivo Survival of Adipose‐Derived Stromal Cells Through Bcl‐2 Overexpression Using a Minicircle Vector
Author(s) -
Hyun Jeong,
Grova Monica,
Nejadnik Hossein,
Lo David,
Morrison Shane,
Montoro Daniel,
Chung Michael,
Zimmermann Andrew,
Walmsley Graham G.,
Lee Min,
Daldrup-Link Heike,
Wan Derrick C.,
Longaker Michael T.
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0035
Subject(s) - progenitor cell , stem cell , regeneration (biology) , biology , microbiology and biotechnology , stromal cell , cell therapy , adipose tissue , mesenchymal stem cell , cancer research , stem cell therapy , wound healing , immunology , endocrinology
For stem cell therapy to be effective, strategies are needed to prevent cell death and allow tissue formation. Using several strategies to overexpress the prosurvival protein Bcl‐2, this study demonstrated a decrease in the mediators of apoptosis in vitro and in vivo, an increased rate of survival within the wound environment, and an increase in tissue regeneration.