Open AccessDissection of the Human Multipotent Adult Progenitor Cell Secretome by Proteomic Analysis
Author(s) -
Burrows Gregory G.,
van't Hof Wouter,
Newell Laura F.,
Reddy Ashok,
Wilmarth Phillip A.,
David Larry L.,
Raber Amy,
Bogaerts Annelies,
Pinxteren Jef,
Deans Robert J.,
Maziarz Richard T.
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0031
Subject(s) - progenitor cell , biology , microbiology and biotechnology , proteomics , progenitor , computational biology , stem cell , gene , genetics
This study used a proteomics approach to characterize and quantify multipotent adult progenitor cell (MAPC) secretome components in vitro in the presence of inflammatory triggers or a tolerogenic CD74 ligand. Findings provide a background for experiments assessing MAPC response to molecular and cellular triggers and events, for eventual programming of MAPCs to be used in a wide range of clinical applications.