Open AccessRepeated Autologous Bone Marrow‐Derived Mesenchymal Stem Cell Injections Improve Radiation‐Induced Proctitis in Pigs
Author(s) -
Linard Christine,
Busson Elodie,
Holler Valerie,
Strup-Perrot Carine,
Lacave-Lapalun Jean-Victor,
Lhomme Bruno,
Prat Marie,
Devauchelle Patrick,
Sabourin Jean-Christophe,
Simon Jean-Marc,
Bonneau Michel,
Lataillade Jean-Jacques,
Benderitter Marc
Publication year - 2013
Publication title -
stem cells translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.781
H-Index - 71
eISSN - 2157-6580
pISSN - 2157-6564
DOI - 10.5966/sctm.2013-0030
Subject(s) - medicine , mesenchymal stem cell , fibrosis , radiation proctitis , bone marrow , pathology , inflammation , angiogenesis , connective tissue , m2 macrophage , cancer research , proctitis , macrophage , immunology , biology , biochemistry , disease , ulcerative colitis , in vitro
Using a preclinical pig model of proctitis, this study investigated the effect of autologous bone marrow‐derived mesenchymal stem cells (MSCs) on high‐dose radiation‐induced proctitis. It was found that repeated injections of MSCs effectively reduced inflammation and fibrosis, representing a promising therapy for radiation‐induced severe rectal damage.